Diabetes Insipidus and Sclerosing Cholangitis in a child may be a clue to the diagnosis of Langerhans’ Cell Histiocytosis: A Case Report

Authors

  • Abdulaziz AlSalloom
  • Salman T Al Malki Department of Pathology, Riyadh Armed Forces Hospital
  • Hadeel Al Mana Department of Pathology, King Faisal Specialist Hospital and Research Centre
  • Martin Burdelski Department of Organ Transplant, King Faisal Specialist Hospital and Research Centre

Abstract

Langerhans cell histiocytosis (LCH) is a rare disease that usually affects children and young adults. Sclerosing cholangitis (SC) can occur in 10-15% of patients with disseminated form of the disease. Central diabetes insipidus (CDI) is a rare disorder that may be caused by a variety of diseases mainly LCH and germinoma especially in children. In this case report, a- 4-year-old girl who is a known case of CDI and a single bone lesion in the left humerus, presented with jaundice, abdominal distention and itching. The diagnosis of SC was made by histopathology on liver biopsy. In this case, we found a link between CDI and SC through LCH, the diagnosis of which was made by histopathology of the explanted liver. The combination of CDI, liver involvement with SC and a single bone lesion is remarkable, since the histological diagnosis of LCH was made outside the biliary tract in the liver parenchyma.

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Published

2013-06-03

How to Cite

AlSalloom, A., Al Malki, S. T., Al Mana, H., & Burdelski, M. (2013). Diabetes Insipidus and Sclerosing Cholangitis in a child may be a clue to the diagnosis of Langerhans’ Cell Histiocytosis: A Case Report. International Journal of Health Sciences, 7(2). Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/428

Issue

Vol. 7 No. 2 (7): ISSUE 14

Section

Case report/case series

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