Diabetes Insipidus and Sclerosing Cholangitis in a child may be a clue to the diagnosis of Langerhans’ Cell Histiocytosis: A Case Report

Abdulaziz AlSalloom
dr.abdulaziz.s@hotmail.com (Primary Contact)
Salman T Al Malki
Department of Pathology, Riyadh Armed Forces Hospital
Hadeel Al Mana
Department of Pathology, King Faisal Specialist Hospital and Research Centre
Martin Burdelski
Department of Organ Transplant, King Faisal Specialist Hospital and Research Centre
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Abstract

Langerhans cell histiocytosis (LCH) is a rare disease that usually affects children and young adults. Sclerosing cholangitis (SC) can occur in 10-15% of patients with disseminated form of the disease. Central diabetes insipidus (CDI) is a rare disorder that may be caused by a variety of diseases mainly LCH and germinoma especially in children. In this case report, a- 4-year-old girl who is a known case of CDI and a single bone lesion in the left humerus, presented with jaundice, abdominal distention and itching. The diagnosis of SC was made by histopathology on liver biopsy. In this case, we found a link between CDI and SC through LCH, the diagnosis of which was made by histopathology of the explanted liver. The combination of CDI, liver involvement with SC and a single bone lesion is remarkable, since the histological diagnosis of LCH was made outside the biliary tract in the liver parenchyma.
Table of Contents
AlSalloom, A., Al Malki, S. T., Al Mana, H., & Burdelski, M. (2013). Diabetes Insipidus and Sclerosing Cholangitis in a child may be a clue to the diagnosis of Langerhans’ Cell Histiocytosis: A Case Report. International Journal of Health Sciences, 7(2). Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/428

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