Are healthcare workers immunized after receiving hepatitis B vaccination according to recommended guidelines? A systematic review and meta-analysis

Abstract

Objectives: Nowadays, it is believed that more than 240 million people worldwide are infected with the hepatitis B virus (HBV), associated with irreversible health-related consequences, represented by hepatic failure, cirrhosis, and hepatocellular carcinoma, and already are ranked as 15th cause of human death around the world.


Methods: A systematic review and a meta-analysis were performed in order to evaluate the effectiveness of vaccination and immunization on health professionals against the hepatitis B virus. The review was registered at the PROSPERO database (CRD42017075643). A search for cross-sectional studies was performed in PubMed, Scopus, Web of Science, LILACS, BBO, Cochrane Library, and in the grey literature. The EPHPP Modified Scale was used to evaluate the internal quality of the studies included.


Results: A total of 1865 articles were identified after the removal of duplicates. Of these, 790 studies remained after screening the titles and abstracts. Finally, ten studies remained after full-text reading for qualitative analysis, all of which were used in the meta-analysis. A significant difference was found in the vaccine protocol for health professionals immunized against hepatitis B, compared to those not immunized. The risk ratio was 7.37 (95% confidence interval [CI] = 3.92 to 13.83; p < 0.00001).


Conclusion: This study showed that the vaccine protocol is effective in immunizing health professionals against hepatitis B.

Keywords:

Health personnel hepatitis b vaccines meta-analysis systematic review
Larocca de Geus, J. ., Foltran de Azevedo Koch, L. ., Kintopp, C., Porto Spada, P. ., Pugsley Baratto, S. ., Fernando Giovanini, A. ., Pizzatto, E., & Maíra Wambier, L. (2020). Are healthcare workers immunized after receiving hepatitis B vaccination according to recommended guidelines? A systematic review and meta-analysis. International Journal of Health Sciences, 15(1), 35–42. Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/5202
Copyright and license info is not available
Author biographies is not available.