Clinical and strategic outcomes of metastatic synovial sarcoma on limb

Authors

  • Sayed Abdulla Jami Ningxia Medical University
  • Siam Al Mobarak Guangxi Medical University
  • Shi Jiandang Ningxia Medical University
  • Zhu Xi
  • M M Sohel Tanvir Ningxia Medical University
  • Sonjoy Sutradhar Monilal Southern Medical University

Keywords:

Synovial sarcoma, limb, metastatic, clinical, strategic

Abstract

Objective: Synovial sarcoma (SS) is one of the most frequent malignant soft-tissue tumors, and nearly 65% arise in the lower extremities. Survival prediction and the risk factors of the patients are poorly understood. Thus, this study examined the survival and prognostic variables of metastatic limb SS (LSS).

Methods: Clinical data of LSS patients with metastasis at the presentation from 1975 to 2017 were obtained from the Surveillance, Epidemiology, and End Results database program database. Kaplan–Meier method was used to describe the survival curves. Univariate and multivariate Cox regression analysis were conducted to reveal the real prognostic predictors.

Results: Male predominance was observed in the metastatic LSS group from a total number of 217 patients. This population was composed of 49.8% not other specified subtype, 32.7% spindle cell subtype, 17.1% biphasic subtype, and 0.5% epithelioid cell subtype. The 3-year overall survival (OS) and cancer-specific survival (CSS)
rates of the entire group were 27.2% and 28.3%, respectively. Tumor size <10 cm, surgery, radiotherapy, and chemotherapy were calculated as independent predictors of improved OS and CSS by multivariate analyses.

Conclusion: SS is still a disease with a poor prognosis. This can increase the survival rate and time by the well-planned treatment.

 

Author Biographies

Sayed Abdulla Jami, Ningxia Medical University

Department of Spinal Surgery, General Hospital of Ningxia Medical University, Ningxia Medical University 804 Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People’s Republic of China.

Siam Al Mobarak, Guangxi Medical University

First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of China.

Shi Jiandang, Ningxia Medical University

Department of Spinal Surgery, General Hospital of Ningxia Medical University, Ningxia Medical University 804 Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People’s Republic of China.

M M Sohel Tanvir, Ningxia Medical University

Department of Spinal Surgery, General Hospital of Ningxia Medical University, Ningxia Medical University 804 Shengli Street, Xingqing District, Yinchuan, 750004, Ningxia, People’s Republic of China.

Sonjoy Sutradhar Monilal, Southern Medical University

Southern Medical University, 1838 Shatai North Street, Baiyun District, Guangzhou, 510515, Guangdong Province, People’s Republic of China.

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Published

2020-11-01

How to Cite

Jami, S. A., Mobarak, S. A., Jiandang, S., Xi, Z. ., Tanvir, M. M. S., & Sutradhar Monilal, S. (2020). Clinical and strategic outcomes of metastatic synovial sarcoma on limb. International Journal of Health Sciences, 14(6), 38–43. Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/5249

Issue

Vol. 14 No. 6 (2020): Nov-Dec

Section

Original Paper

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