Association of IL-17A promoter region SNP-rs2275913 with urinary bladder cancer
Abstract
Objective: Urinary bladder cancer (UBC) is the fourth most common cancer among men and tenth most common cancer in women. This study investigated an association of IL-17A promoter region SNP-rs2275913 with urinary bladder cancer in Pakistani population.
Methods: Population based study was designed with 127 UBC patients and 100 healthy individuals. Only UBC Patients were included and other diseases hepatitis or any other malignancy/cancer were excluded from the study. PCR-RFLP technique was used to genotype the rs2275913 SNP in patients and control. Linear regression analysis was performed on the genotype data and allelic frequency data. Online statistical tool was used to calculate ratio of odds.
Results: Linear regression analysis showed that there was no association between rs2275913 SNP and UBC patients in the dominant model (OR=0.815, CI=0.415-1.6), recessive model (OR=0.389, CI=0.014-5.565), co-dominant model (OR=0.376, CI=0.013-5.420) and (OR=0.855, CI=0.427-1.713). Moreover, among the UBC samples, low grade non-muscle invasive UBC samples dominant model (OR=0.722, CI=0.316-1.637), recessive model (OR=0.000, CI=0.000-5.864), co-dominant model (OR=0.864, CI=0.030-12.668) and (OR=0.788, CI=0.341-1.806) did also not show any association. When same analysis was performed for high grade muscle invasive UBC, dominant (OR=0.936, CI=0.403-2.155), recessive model (OR=0.875, CI=0.031-12.696) and co-dominant model (OR=0.864, CI=0.030-12.668,) and (OR=0.942, CI=0.394-2.232) did not show any association.
Conclusions: Results revealed that, rs2275913 did not show any associated with the high risk of UBC in Pakistani population. Some limitations of the studies is firstly, the samples size and other is detailed information on UBC and role of inflammation.
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