Relation of Insulin Resistance and Liver Fibrosis Progression in Patients with Chronic
Abstract
Background: Hepatitis C virus (HCV) infection can predispose to the development of insulin resistance before diabetes occurs.
Such a potential link is particularly cogent in light of recent data indicate that diabetes may be associated with increased hepatic
fibrosis progression in patients with chronic HCV infection. The aim of the study is to determine the prevalence of insulin
resistance in non diabetic patients with chronic hepatitis C and its relation to liver fibrosis.
Methods: Thirty eight patients with chronic liver diseases. They subdivided into 2 groups; chronic hepatitis C (CHC) with
elevated liver enzymes and CHC with normal liver enzymes. Age and sex matched 12 healthy subjects as control group. All
subjects were subjected to Careful history and copmlete examination with stress upon symptoms and signs of chronic liver
diseases. Investigations include liver function tests; viral markers (Anti HCV antibodies & PCR for HCV). Serum fasting glucose;
serum fasting insulin; homeostasis model assessment (HOMA), liver biopsy and abdominal ultrasound.
Results: No correlation between viral load and hepatic fibrosis in HCV infected patients. Liver fibrosis is considerably higher
among HCV patients with elevated serum transaminase levels. Insulin resistance is present in HCV infected cases compared
with control group and it is positively correlated with liver fibrosis.
Conclusion: The present data support the hypothesis that insulin resistance may increase the rate of fibrosis progression in
non diabetic patients with chronic HCV. Follow up of hyperinsulinemia by serial measurement of HOMA test in non diabetic HCV
infected patients may be a biochemical indicator for progression of liver fibrosis.
Such a potential link is particularly cogent in light of recent data indicate that diabetes may be associated with increased hepatic
fibrosis progression in patients with chronic HCV infection. The aim of the study is to determine the prevalence of insulin
resistance in non diabetic patients with chronic hepatitis C and its relation to liver fibrosis.
Methods: Thirty eight patients with chronic liver diseases. They subdivided into 2 groups; chronic hepatitis C (CHC) with
elevated liver enzymes and CHC with normal liver enzymes. Age and sex matched 12 healthy subjects as control group. All
subjects were subjected to Careful history and copmlete examination with stress upon symptoms and signs of chronic liver
diseases. Investigations include liver function tests; viral markers (Anti HCV antibodies & PCR for HCV). Serum fasting glucose;
serum fasting insulin; homeostasis model assessment (HOMA), liver biopsy and abdominal ultrasound.
Results: No correlation between viral load and hepatic fibrosis in HCV infected patients. Liver fibrosis is considerably higher
among HCV patients with elevated serum transaminase levels. Insulin resistance is present in HCV infected cases compared
with control group and it is positively correlated with liver fibrosis.
Conclusion: The present data support the hypothesis that insulin resistance may increase the rate of fibrosis progression in
non diabetic patients with chronic HCV. Follow up of hyperinsulinemia by serial measurement of HOMA test in non diabetic HCV
infected patients may be a biochemical indicator for progression of liver fibrosis.
Mohamed, H. R., Abdel-Azziz, M. Y., Zalata, K. R., & Abdel-Razik, A. M. M. (2009). Relation of Insulin Resistance and Liver Fibrosis Progression in Patients with Chronic. International Journal of Health Sciences, 3(2). Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/8
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Copyright and license info is not available