Therapeutic potentials of catalase: Mechanisms, applications, and future perspectives
Abstract
Catalase, an enzyme ubiquitous in living organisms, plays a pivotal role in mitigating oxidative stress by catalyzing the decomposition of hydrogen peroxide (H2O2) into water and oxygen. Mechanistically, this action prevents the accumulation of reactive oxygen species (ROS) and consequent oxidative damage to cells and tissues. Understanding the molecular mechanisms underlying catalase activity, exploring its therapeutic applications across diverse disease contexts, addressing challenges in catalase-based therapies, and advancing novel strategies for enhanced efficacy are essential steps towards harnessing its full therapeutic potentials. In the medical realm, catalase shows promise for treating oxidative stress-related diseases such as neurodegenerative disorders, cardiovascular diseases, and inflammatory conditions. This article explores the therapeutic potentials of catalase, focusing on its mechanisms, applications, and future perspectives.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).