Induction of Labor with Prostaglandin E2 in Women with Previous Cesarean Section and
Abstract
Background: Induction of labor is common in obstetric practice. According to the most current studies, the rate varies from 9.5
to 33.7 percent of all pregnancies annually. In the absence of a ripe or favorable cervix, a successful vaginal birth is less likely.
Therefore, cervical ripening or preparedness for induction should be assessed before a regimen is selected. To objective is to
study the pregnancy outcome of induction of labor with prostaglandin E2 (PGE2) in women with one previous lower segment
cesarean section.
Methods : A prospective study was conducted at Maternity & Children Hospital, Buraidah (Qassim), Saudi Arabia. The sample
included 153 consecutive women with one previous cesarean section, of whom 75 underwent induction of labor (study group)
and 78 were admitted with spontaneous onset of labor (control group). Vaginal tablets of PGE2 were used for cervical ripening
in the study group. Mode of delivery, neonatal outcome, indications for cesarean section, and rate of uterine rupture were
compared between the groups.
Results : There were no significant differences between the study and control groups in mean (_S.D.) maternal age (30:9 _ 4:7
years versus 31:2 _ 4:8 years, P ¼ 0:6), gestational age at delivery (39:2 _ 1:8 weeks versus 39:3 _ 1:6 weeks, P ¼ 0:36),
overall rate of cesarean section (24% versus 20.5%, P ¼ 0:8), rates of low 5-min Apgar score (3.1% versus 3.7%, P ¼ 0:67) or
cesarean section performed for non-reassuring fetal heart rate (9.3% versus 7.69%, P ¼ 0:1). There were no cases of uterine
rupture, in both groups.
Conclusion : The findings suggest that induction of labor in women with one previous cesarean section does not increase the
risk of cesarean section rate and does not adversely affect immediate neonatal outcome. We cautiously suggest that when
there is no absolute indication for repeated cesarean section, induction of labor may be considered.
to 33.7 percent of all pregnancies annually. In the absence of a ripe or favorable cervix, a successful vaginal birth is less likely.
Therefore, cervical ripening or preparedness for induction should be assessed before a regimen is selected. To objective is to
study the pregnancy outcome of induction of labor with prostaglandin E2 (PGE2) in women with one previous lower segment
cesarean section.
Methods : A prospective study was conducted at Maternity & Children Hospital, Buraidah (Qassim), Saudi Arabia. The sample
included 153 consecutive women with one previous cesarean section, of whom 75 underwent induction of labor (study group)
and 78 were admitted with spontaneous onset of labor (control group). Vaginal tablets of PGE2 were used for cervical ripening
in the study group. Mode of delivery, neonatal outcome, indications for cesarean section, and rate of uterine rupture were
compared between the groups.
Results : There were no significant differences between the study and control groups in mean (_S.D.) maternal age (30:9 _ 4:7
years versus 31:2 _ 4:8 years, P ¼ 0:6), gestational age at delivery (39:2 _ 1:8 weeks versus 39:3 _ 1:6 weeks, P ¼ 0:36),
overall rate of cesarean section (24% versus 20.5%, P ¼ 0:8), rates of low 5-min Apgar score (3.1% versus 3.7%, P ¼ 0:67) or
cesarean section performed for non-reassuring fetal heart rate (9.3% versus 7.69%, P ¼ 0:1). There were no cases of uterine
rupture, in both groups.
Conclusion : The findings suggest that induction of labor in women with one previous cesarean section does not increase the
risk of cesarean section rate and does not adversely affect immediate neonatal outcome. We cautiously suggest that when
there is no absolute indication for repeated cesarean section, induction of labor may be considered.
Alsayegh, A.-K., Roshdy, S., Hany, A. A., & Maha, Y. S. (2007). Induction of Labor with Prostaglandin E2 in Women with Previous Cesarean Section and. International Journal of Health Sciences, 1(2). Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/86
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
Copyright and license info is not available