Molecular Genetic of Atopic dermatitis: An Update

Authors

  • Hani A. Al-Shobaili Department of Dermatology, College of Medicine, Qassim University, Buraidah, KSA.
  • Ahmed A. Ahmed Research Centre, College of Medicine, Qassim University, Buraidah, KSA.
  • Naief Alnomair Prince Sultan Medical and Military City, Riyadh, KSA.
  • Zeiad Abdulaziz Alobead King Fahad Medical City, Riyadh, KSA.
  • Zafar Rasheed Department of Medical Biochemistry, College of Medicine, Qassim University, Buraidah, KSA.

Keywords:

Atopic dermatitis, molecular genetics, immune genes, cytokine, chemokine, drug-metabolizing genes.

Abstract

     Atopic dermatitis (AD) is a chronic multifactorial inflammatory skin disease. The pathogenesis of AD remains unclear, but the disease results from dysfunctions of skin barrier and immune response, where both genetic and environmental factors play a key role. Recent studies demonstrate the substantial evidences that show a strong genetic association with AD. As for example, AD patients have a positive family history and have a concordance rate in twins. Moreover, several candidate genes have now been suspected that play a central role in the genetic background of AD. In last decade advanced procedures similar to genome-wide association (GWA) and single nucleotide polymorphism (SNP) have been applied on different population and now it has been clarified that AD is significantly associated with genes of innate/adaptive immune systems, human leukocyte antigens (HLA), cytokines, chemokines, drug-metabolizing genes or various other genes. In this review, we will highlight the recent advancements in the molecular genetics of AD, especially on possible functional relevance of genetic variants discovered to date.

 

Keywords: Atopic dermatitis, molecular genetics, immune genes, cytokine, chemokine, drug-metabolizing genes. 

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Published

2016-02-29

How to Cite

Al-Shobaili, H. A., Ahmed, A. A., Alnomair, N., Alobead, Z. A., & Rasheed, Z. (2016). Molecular Genetic of Atopic dermatitis: An Update. International Journal of Health Sciences, 10(1). Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/1132

Issue

Vol. 10 No. 1 (2016)

Section

Reviews

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