Hemophagocytic histiocytosis: A Clinicopathological correlation

Authors

  • Waseem Iqbal
  • Abdulaziz Ajlan Alsalloom
  • Khalid Shehzad
  • Faisal Mughal
  • Zafar Rasheed

Keywords:

Hemophagocytic syndrome, hemophagocytosis, histiocytosis, mononuclear phagocyte system

Abstract

Objectives: Histiocytic hyperplasia with hemophagcytosis (HP) is relatively uncommon condition that has often been mistaken in the past for neoplastic disorders. This study was undertaken to investigate the possible etiology of HP, its intensity in the bone marrow and also its effect on hematological parameters with the extent of disease activity.

Methods: Blood samples were collected and bone marrow examination was performed in 250 patients with varied etiology showing HP. Complete bloodcounts, reticulocyte count, and RBC morphology were determined. HP was examined in the bone marrow smears by leishman staining. Severity of HP was determined by grading of its intensity in the bone marrow smears.

Results:  Our data showed variable degree of HP (mild, moderate, severe) in the bone marrow smears of patients having different underlying disorders. Hemophagorytic syndrome (HPS) with clinical and biochemical derangements was found in 24 (9.6%) patients. HPS was mostly associated with infection. The etiological distribution in different group of disorders was ;nonmalignant-hematological-conditions (NMHC) (56.80%), infections (24.80%), storage disorders (4.40%), malignant hematological conditions (4.40%) autoimmune disorders (1.20%) and miscellaneous group (8.40%). Distribution of patients in different grades of intensity of HP was ;grade I (35.50%; mild), grade II (45.50%; moderate) and grade III (19.60%; severe).

Conclusion: We conclude that severe degree of HP has profound effect on hematological parameters particularly hemoglobin and platelet counts. This phenomenon may presents as HPS with fatal outcome. We also conclude that there was no effect of age on either intensity of HP or on blood counts.

 

Downloads

Published

2017-02-06

How to Cite

Iqbal, W., Alsalloom, A. A., Shehzad, K., Mughal, F., & Rasheed, Z. (2017). Hemophagocytic histiocytosis: A Clinicopathological correlation. International Journal of Health Sciences, 11(1). Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/1579

Issue

Vol. 11 No. 1 (2017)

Section

Original Paper

License


Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).

Most read articles by the same author(s)

1 2 3 > >>