Protective effects of N-acetylcysteine and S-adenosyl-Lmethionine against nephrotoxicity and immunotoxicity induced by ochratoxin A in rats

Nuha Alkhattabi
Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Fares K. Khalifa
Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
Huda A. Al Doghaither
haldoghaither@kau.edu.sa (Primary Contact)
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
Ayat B. Al-Ghafari
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
Nesrin I. Tarbiah
Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
Aliaa Sabban
Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
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Abstract

Objective: The present study was designed to investigate the nephroprotective and immunoprotective effects of S-adenosyl-L-methionine (SAMe) in comparison to N-acetylcysteine (NAC) against ochratoxin A (OTA) – intoxication.
Methods: Forty-eight adult male Sprague–Dawley rats were categorized into four
groups: Control; OTA intoxication (5 mg OTA/kg diet); OTA + NAC, rats received 200 mg NAC/day before feeding balanced diet contaminated with OTA; and (OTA  SAMe). Rats received 200 mg SAMe/day dissolved in distilled water orally just
before feeding a balanced diet contaminated with OTA.
Results: OTA administration altered serum kidney function biomarkers. These effects were pronouncedly alleviated by treatment with NAC. Results revealed a correlation between OTA-induced immunotoxicity and the reduced white blood cell (WBC) count. Treatments with SAMe significantly improved the WBCs count and hemoglobin concentration.
Conclusion: NAC and SAMe have a protective role against nephrotoxicity and immunotoxicity induced by continuous administration of OTA. NAC was more effective in reducing OTA nephrotoxicity, whereas SAMe was more potent than NAC
in reducing OTA immunotoxicity.

Keywords:

Immunotoxicity Mycotoxins N-Acetyl Cysteine nephrotoxicity ochratoxin A, S-adenosyl-L-methionine
Table of Contents
Alkhattabi, N. A., Khalifa, F., Al Doghaither, H., Al-Ghafari, A., Tarbiah, N. I., & Sabban, A. (2024). Protective effects of N-acetylcysteine and S-adenosyl-Lmethionine against nephrotoxicity and immunotoxicity induced by ochratoxin A in rats. International Journal of Health Sciences, 18(2), 17–24. Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/8454
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