The exploration of therapeutic potential of bioflavonoids in metabolic acidosis and inflammation-associated with acute kidney injury: Therapeutic potential of bioflavonoids in acute kidney injury

Authors

  • Maha M. Al-Bazi Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
  • Abeer A. Banjabi Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
  • Fares K. Khalifa Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
  • Bahiya Osrah Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
  • Hayat M. Albishi Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
  • Aliaa M. Sabban Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
  • Sahar A. Alkhodair Department of Biochemistry, Faculty of Science, King Abdul-Aziz University
  • Rasha H. Hussein Department of Biological sciences, College of Science, University of Jeddah, Saudi Arabia

Keywords:

Acute kidney injury, bioflavonoids, genistein, hesperidin, inflammation, metabolic acidosis, nephrotoxicity, quercetin

Abstract

Objectives: The goal of this study was to estimate and compare the prospective therapeutic impacts of different types of bioflavonoids (flavonols, flavanones, and isoflavones) on acute kidney injury (AKI) induced by glycerol in male rats.
Methods: Fifty adult male albino rats (Sprague-Dawley) were separated into five groups: G1, control; G2, rats injected (i.m.) by glycerol (50%) (10 mL/kg b. w.) to induce AKI; G3, G4, and G5, rats received quercetin (QUR), hesperidin (HSP), and genistein (GEN), respectively, after 24 h of glycerol injection for 42 successive days.
Results: Treatment with bioflavonoids improved the renal tissue levels of antioxidant biomarkers (superoxide dismutase, glutathione, catalase, nitric oxide, inflammatory cytokines (interleukin-6, interleukin-1 βeta, nuclear factor kappa-B, tumor necrosis factor-alpha), kidney function markers (creatinine, urea, urine albumin creatinine ratio, albumin) as compared to nephrotoxic groups. QUR extract reduced the serum level of kidney function parameters in glycerol-injected rats more significantly (P ≤ 0.01) than HSP and GEN. Results demonstrated that the GEN as a therapeutic natural agent exhibited the greatest advancement in urine values, followed by the QUR and HSP respectively when compared to the AKI group.
Conclusion: The study results demonstrated the therapeutic effect of bioflavonoids against AKI induced by glycerol. Different types of bioflavonoids could reduce oxidative stress, inhibit the production of inflammatory mediators and cytokines, and improve renal function.

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Published

2025-03-01

How to Cite

Al-Bazi, M., Banjabi, A., khalifa, F., Osrah, B., Albishi, H., Sabban, A., Alkhodair, S., & Hussein, R. (2025). The exploration of therapeutic potential of bioflavonoids in metabolic acidosis and inflammation-associated with acute kidney injury: Therapeutic potential of bioflavonoids in acute kidney injury. International Journal of Health Sciences, 19(2), 57–65. Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/8848

Issue

Vol. 19 No. 2 (2025): Mar-Apr

Section

Original Paper

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