Monocytopenia; Induction by Vinorelbine, Cisplatin and Doxorubicin in Breast, Non-Small Cell Lung and Cervix Cancer Patients

Taha Nazir
taha.nazir@uos.edu.pk (Primary Contact)
Faculty of Pharmacy, University of Sargodha, Sargodha 40100 Pakistan
Nida Taha
Azahrul Islam
Suraj Abraham
Adeel Mahmood
Mazhar Mustafa
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Abstract

Background: The neoplasm is still a potential threat for breast, Non-Small Cell Lung (NSCL) and cervix cancer patients. Those gradually invade into other body organs, inducing complex pathological complications. Whereas, the anticancer drugs suppress the bone marrow, resulting serious hematological toxicities. Thus, the monocytic toxicity may the chance of infections, particularly in AID’s patients.

Objective: We aimed this retrospective study to investigate the monocytopenia induced by vinorelbine following chemotherapy in cancer patients. 

Patients and method: A total 60 adult cancer patients were divided into two groups; Group-1 patients received the treatment of Vinorelbine alone while group 2 patients received Vinorelbine based combination chemotherapy.

Result: The overall comparison of mean monocyte count (×103 per µl) with time showed a significant statistical difference (p value <0.001) for G-I and no significant difference for G-II (p value <0.08). The independent comparison of mean values for two groups at every week confirms the non-significant statistical difference during all of the five weeks (p values 0.551, 0.112, 0.559, 0.372, 0.468 respectively). In addition of that, the comparison of mean values observed before therapy with that of week 4 (after therapy) showed significant difference in G-I (p value <0.001) and non-significant in G-II (p value 0.053).

Conclusion: Monocytopenia is induced in both of the chemotherapy protocols allows the clinical oncologists and consultant physicians to select either of the chemotherapy protocol. The therapeutic efficacy should constitute the intervening consideration to treat the breast, cervix and NSCL (Non-Small Cell Lung’s) cancers.

 

Keywords:

Monocytopenia Vinorelbine Cisplatin Doxorubicin Breast Cancer NSCLC
Table of Contents
Nazir, T., Taha, N., Islam, A., Abraham, S., Mahmood, A., & Mustafa, M. (2016). Monocytopenia; Induction by Vinorelbine, Cisplatin and Doxorubicin in Breast, Non-Small Cell Lung and Cervix Cancer Patients. International Journal of Health Sciences, 10(4). Retrieved from https://pub.qu.edu.sa/index.php/journal/article/view/990

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Author Biography

Taha Nazir, Faculty of Pharmacy, University of Sargodha, Sargodha 40100 Pakistan
Dr. Nazir Nazir has more than fifteen year’s professional, academic and research experience. His expertise are related to the discipline of pharmacology, epidemiology, therapeutics and clinical pharmacy along with exceptional knowledge of biological techniques. He has teaching experience to Pharm D and M.Phil students at certain universities. He has worked at different positions; Associate Dean, Associate Professor, scientific executive and scientific head with different renowned institutions of the world. He has strong ability to quickly absorb and implement new pedagogical techniques. His other professional expertise includes; academic teaching, pharmaceutical manufacturing, marketing and product development. His laboratory and research expertise include pharmacological, microbiological, pharmaceutical and biotechnology laboratory techniques. Dr. Taha Nazir was awarded Ph.D in Microbiology by the Quid -I-Azam University, Islamabad, Pakistan. He was awarded the degrees of M. Phil (Pharmacology) by Agriculture University Faisalabad and Bachelor of Pharmacy from University of the Punjab, Lahore. He has several research articles published in prestigious international pharmaceutical journals and wrote three books published by leading Pakistani publishers titled Applied Pharmacotherapy (2008); Clinical and Pharmaceutical Management of Diseases (2009); and Manual of Experimental Work of Pharmacology & Therapeutics, (2007). Moreover; he is part of different pharmaceutical professional organisations and prestigious research journals. Currently, Dr. Taha Nazir is working as Assistant Professor with Faculty of Pharmacy, University of Sargodha. He is also entrepreneur the Drug Discovery & Technology Development Inc.