Candida auris: An emerging fungus that presents a serious global health threat


Candida auris is a fungal species that belongs to Ascomycetous fungi which are generally recognized as the sac fungi or ascomycetes.1 It is the biggest phylum of Fungi, in which over 64,000 fungal species are included. C.auris belongs to  the genus Candida that grows as a yeast.2 Genomic analysis of C.auris DNA  has revealed that it is a distinct fungal species bearing close resemblance of the phylogenetic profiles of Candida haemuloniiCandida ruellia C. pseudohaemulonii and  C. duobushaemulonii.4 Its name is derived from the Latin word “auris”  wich means “ear”,  as it was initially discovered  in the year 2009 in Japan from the ear canal of a 70-year-old woman at the Tokyo Metropolitan Geriatric Hospital. Latter in 2011 it was reported in South Korea following its  spread across Asia and Europe, and in the year 2013 it was reported in  United states.3 Till present day it has been reported in almost thirty five  countries located in all continents, with the exception of Antarctica.4,5 C. auris  is resistant to majority of antifungal drugs, hence establishing itself as a new example of one of the world's most obdurate health threats resulting from of infections caused by various drug resistant organisms for example Carbapenamese resistant Klebsella pneumoniae, Vancomycin resistant Enterococci (VRE), Methicillin resistant Staphlylococcus aureus( MRSA).6 C. auris can endure on the surfaces of a  healthcare setting resulting in nosocomial infections as it can spread in between patients admitted in that  healthcare facility. C. auris can survive on a broad range of dry and moist surfaces, including plastic where the pathogen may dwell for up to fourteen days.7   C. auris is found  to be resistant to a broad range of disinfectants that includes various quaternary compounds and cationic surface active products.  Although the precise mode of transmission of C.auris is yet to be recognized, evidence suggests that C. auris spread is chiefly associated with direct or indirect contact with the contaminated surfaces located in a health care setting as well as from healthcare personnel. Persistent outbreaks have been reported accusing transmission through hand and contaminated of surfaces.8.9

Patients who are immunocompromised or  have an extensive hospital  stay in an intensive care unit  or who had previously received antibiotic or antifungal medications are particularly more prone to be infected by C.auris. Healthcare facilities in different countries have reported that C. auris has been causing severe disease in patients. In several patients, this yeast has also been reported to enter the bloodstream resulting in spread of infection in different parts of the body, causing life threatening  invasive infections.10,11 As this  yeast is often resistant to most of the commonly used antifungal drugs, it leads in difficulty to treat such infected patients hence leading to an increase in morbidity and mortality rate. Fungal identification methods implied to identify yeasts in various clinical specimens, by the clinical laboratories,  frequently misidentify C. auris  as other yeasts therefore making the diagnosis and control of this multi drug resistant pathogen an enormous challenge. Morphologically C. auris is a budding yeast with cells that are approximately  2.5-5.0 micrometers in size and are arranged singly,  in pairs or even in groups. It grows well at a temperature of 40 degrees Celsius however  the growth slows down at 42 degrees Celsius.  C. auris does not  form hyphae or pseudohyphae. Though, if it is grown under high-salt stress, such as on yeast extract, tryptone, and dextrose (YTD) with 10% NaCl, and depletion of heat-shock proteins (HSP), it can result in   production of  pseudohyphae like forms.12 The appearance of C. auris on culture medium varies depending upon the culture  media. Globally the most common media used for fungal growth   is Sabouraud’s dextrose agar, on which C. auris will create smooth, white to cream-colored colonies.13 Whereas on CHROM agar, C. auris will appear in different colors  ranging from pale to dark pink. The ability of C. auris to build up resistance to several commonly used antifungal drugs may be a vital factor that had contributed for its high rate of mortality.14 Antifungal susceptibility data published so far reflects that a number of C. auris strains demonstrate elevated minimum inhibitory concentration (MIC) for three major classes of antifungal drugs, which includes azoles, polyenes, and echinocandins.  Echinocandins were considered as the first line therapy for treating C. auris infection if resistance to azoles and amphotericin B is detected. However as the resistance to echinocandins has also been established, patients should undergo close follow up and microbiological culture based reassessment to detect therapeutic failure and consultation with an infectious diseases expert is recommended.

Scrupulous awareness of infection prevention and control, along with strict implementation of hand hygiene for healthcare personnel and healthcare facility visitors either by  hand washing with soap and water or hand sanitizing with an alcohol-based hand rub is a vital step to control the spread of C.auris. Moreover the healthcare personnel should strictly follow the basic infection prevention and control measures that include the proper use of gowns and gloves, appropriate discarding of medical waste and sterilizing or effectively disinfecting equipment and surfaces. Health care facilities should have mounted directions to a specific ward or facility so that the visitors can follow those facility directions in order to prevent the spread of infection. Lastly the most crucial step is environmental cleaning and disinfection, healthcare cleaning products that have a sporicidal activity or  hydrogen peroxide containing solutions can contribute in an effective cleaning of  surfaces in a healthcare facilities leading to decrease in C. auris colony-forming unit (CFU).15 Those patients who are colonized or with  suspected C. auris infection should be kept in isolation under strict contact precautions until microbiological screening and diagnostic results are obtainable. Patients who are referred from the  institutions where C. auris has been  isolated, should be screened for C.auris colonization. Suggested screening sites are axilla, groin, nose, throat, and rectal swab. Other high risk sites  include cannula or catheter entry sites, wounds and endotracheal secretions. After a  patient is discharged from a  healthcare facility, environmental decontamination  procedures with Chlorine-based detergents, ultraviolet light, and hydrogen peroxide vapor demonstrated  have shown to be effective in environmental decontamination.16 In order to restrain transmission it is also recommended that central and peripheral line catheter , urinary catheter, and tracheostomy sites should be strictly monitored and incase of any sign of colonization or infection of central catheters or other invasive devices, should be removed, as it has  shown to play a significant role in subsiding the candidemia and improving the clinical outcome.auris strains may continue to emerge independently and concurrently throughout the globe in the coming years that’s why it is essential that the healthcare workers should be aware about this notorious organism and infection control policies regarding control and spread of C. auris should be design and implemented along with an enhanced diagnostic and therapeutic strategies.

Shariq, A. ., Rasheed, Z., S Alghsham, R., & Al Abdulmonem, W. (2023). Candida auris: An emerging fungus that presents a serious global health threat. International Journal of Health Sciences, 17(2). Retrieved from
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